Evo Devo Cifras

[Intro]
N C
Huxley
B  Mac
Oh Carroll, Carroll
Gould, Stephen Jay yeah
D-D-D-D-Davidson and Peter
 
Bm                                    G
See one cell divide and decide on a thousand fates
 D                              A
Did you ever figure how they know?  (B  Mac)
Bm                                       G
We  are built of modules combined in a planned out way
D                                      A
Each new piece must be told where to go     Oh
 
[Verse 1]
 Bm                                        G
Now there's a science helping us to understand
                                          D
How our cells encode this architectural plan
                                      A
Signalling each other with genetic tools oh  (oh yeah)
 Bm                                        G
Wow phenotype the interface for mouse and man
                                   D
Genotype the files and the subprograms
                                                  A
What then are the switches, circuit boards and boot code?
 
[Chorus]
     Bm
Evo-Devo
                                        G
Looking at the logic in the ways that we grow
                                  D
Every gene directed by a signal key code
                                         A
Proteins that can activate, enhance or veto
     Bm
Evo-Devo
                                             G
Signals are controlled by other genes that signal
                                D
Calculating in a network labyrinthal
                                               A
Where the heart and liver and the hands and feet go
 
[Post-Chorus]
 Bm                                                G
Signal mapping tells each region what it ought to be yo
                                D
 With circuits so deeply built upon
                           A
They're older than the Pale-o (The Paleozoic Era baby)
Bm                                            G
In a crucial pathway changes tend to get torpedoed
                      D
Where they go calamity goes
                      A
 As this cyclopic sheep knows
 
[Verse 2]
                               Bm
 See down they cascade like a domino
 
Like you and I drosophila
                       G
The path that makes us optical
 
Was laid a long long time ago
                 D
Back before we blew up the cambrian like a bomb bomb
                A
Now my eye protein can make you see out of your bom bom
                      Bm
And Hedgehog and its relatives like Indian and Sonic
                     G
Set up set up in a gradient on segments embryonic
                     D
Split forebrains and asymmetric parts depend upon it
               A
Flipping on genetic switches and logic
 
[Pre-Chorus]
             Bm
From devo to evo; Adult and embryo
               G
Mostly don't evolve in the genes of the genome
             D
Safer the mutation aimed at regulation
                    A
Keep the building blocks and swap their activation
             Bm
From devo to evo; Parts have alter egos
           G
Homologs evolved from repeats in the schema
                 D
Switch a couple bases in the proper places
                     A
You'll be watching flies grow legs out of their faces oh yeah
 
[Chorus]
A    Bm
Evo-Devo
                                        G
Stick around for Modern Synthesis the sequel
                                  D
Only by combining can a new theory grow
                             A
Evolution and development amigos
     Bm
Evo-Devo
                                     G
Signals trigger patterns of complexity so
                                       D
Switching up the switches of a signalling node
                                   A
Gives a modular and simple way to evolve
 
[Post-Chorus]
 Bm                                         G
Look at how our spinal segments generate a neat row
                   D
Built on a molecular clock
                    A
One cycle, one vertebra (One vertebra one vertebra baby)
  Bm                                              G
Speeding up its rate is snakes' developmental cheat code
                             D
That and where a lizard's feet grow
                        A
They turn off distal aminos
 
[Verse 3]
     Bm
Evo-Devo
                                          G
This is how we go from single cells to people
                                  D
Every generation and in life primeval
                                     A
Life in variations endless and beautiful
 
[Outro]
             Bm
From devo to evo; Larva to mosquito
                G                          ( )
Patterns are resolved as the signals pro  (ceed yo)
                         D
Map out a gene with a glow tag
                       A                            ( )
Kill it with a morpholino(Short oligo morpholi  (no baby))
             Bm
From devo to evo; Voyage of the Beagle
             G                              ( )
Body plans evolve when proteins steer the  (genome)
                            D
In this manner life's beauty grows
                 A
 Aesthetica in vivo
     Bm
Evo-Devo
X